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Search Results for " interleukin-18-binding protein "

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Cat. No.	Product Name	Species	Expression System
TMPY-05492	IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) interleukin 18 binding protei...	Human	HEK293 Cells
	IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is AAD17187.1.
TMPY-00846	IL-18BP Protein, Human, Recombinant (His) interleukin 18 binding protei...	Human	HEK293 Cells
	IL-18BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is A0A024R5G2.
TMPY-01111	IL-18BP Protein, Mouse, Recombinant (His) IL-18BP,MC54L,interleukin 18 ...	Mouse	HEK293 Cells
	IL-18BP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.4 kDa and the accession number is Q9Z0M9.
TMPJ-00072	IL-18BPd Protein, Mouse, Recombinant (hFc) Interleukin 18 Binding Protei...	Mouse	HEK293 Cells
	Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF-γ, which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain which is essential to the bin...
TMPK-00492	IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated Igifbp,Interleukin-18-binding	Cynomolgus	HEK293 Cells
	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombi...
TMPK-00491	IL-18BP Protein, Cynomolgus, Recombinant (His) Igifbp,Interleukin-18-binding	Cynomolgus	HEK293 Cells
	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein, Cynomolgus, Recombinant (His) is expressed i...
TMPJ-00074	IL-18BP Protein, Human, Recombinant (hFc) Interleukin-18-binding protei...	Human	HEK293 Cells
	Interleukin-18-binding protein, also known as Tadekinig-alfa and IL18BP, contains 1 Ig-like C2-type domain. IL18BP is constitutively expressed and secreted in mononuclear cells. IL18BP functions as an IL18 inhibitor. IL18BP binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. It has been shown that IL18BP may be a promising molecular approach to inhibit neointimal hyperplasia and arteriosclerosis progression following coronary and peri...
TMPJ-00070	IL-18 Protein, Human, Recombinant (His) GIF,IL-1 γ,白细胞介素,Iboctadekin,Interleukin-18	Human	HEK293 Cells
	Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After...
TMPJ-01056	IL-18 Protein, Mouse, Recombinant (His) Interferon γ-inducing factor,Interleukin-1 gamma,Ig...	Mouse	E. coli
	Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins...
TMPJ-00789	Flagellin Protein, Salmonella Typhimurium, Recombinant flaF,Phase 1-I flagellin,Flagellin,fliC,hag	Salmonella typhimurium	E. coli
	Flagellin is the major structural protein monomer of bacterial flagella. Flagellin through binding to its receptor and activation of antigen presenting cells stimulates the innate and adaptive immune responses. Flagellin is used as an effective systemic or mucosal adjuvant to stimulate the immune system. Flagellin is an agonist of Toll-like receptor 5 (TLR5), a pattern recognition receptor (PRR) of the innate immune system expressed on the basolateral surface of intestinal epithelial cells and o...